Depression is more than feeling low — it’s a serious medical condition that affects mood, motivation, energy, and overall quality of life.
Major Depressive Disorder (MDD), commonly known as depression, is a serious medical condition characterised by persistent low mood, loss of interest or pleasure, and reduced energy.
Depression can affect how a person thinks, feels, and functions day-to-day, often leading to disturbances in sleep, appetite, concentration, and self-esteem. It is distinct from ordinary sadness or grief—it involves a sustained change in mood lasting at least two weeks and significantly impairs quality of life and daily functioning.
Behind depression lies a complex interplay of brain chemistry, hormones, stress, and environment — influencing how we think, feel, and connect with the world.
Depression arises from a complex interaction of biological, psychological, and social factors. Genetics, trauma, chronic stress, medical illness, and neurochemical changes in the brain can all play a role. While conventional antidepressants and psychotherapy are effective for many, some individuals experience treatment-resistant depression (TRD)—where symptoms persist despite multiple standard treatments.
Depression often involves a combination of emotional, cognitive, and physical symptoms.
Recognising depression is the first step in seeking help. Depression can look different for each person, but common symptoms may include:
For many people, standard treatments like antidepressants or psychotherapy aren’t enough. At Anodyne, we offer treatments for people with treatment resistant depression.
Explore how ketamine can be used in treatment-resistant depression to help improve mood, relieve distress, and support long-term recovery.
Ketamine therapy has been shown to improve depression, particularly in people with treatment resistant illness. Research has shown ketamine rapidly reduces depressive symptoms and suicidal thoughts, often within hours, providing a crucial window of safety and relief.
Stellate Ganglion Block (SGB) may also be considered in selected cases where post-traumatic stress disorder (PTSD) and trauma related anxiety and stress responses play a defining role.
What makes Anodyne different is our dual expertise in psychiatry and pain medicine.
We don’t just treat symptoms — we address the underlying biological pathways involved in depression. This means patients — and referring clinicians — can trust our process to be both clinically rigorous and patient-centred.
We understand how exhausting depression can be, especially when treatments have failed.
At Anodyne, you’ll be supported by a compassionate team with extensive experience in treatment-resistant conditions.
Our accredited clinics provide safe, comfortable environments where you are monitored throughout treatment and guided at every step.
Take the Next Step
If you or someone you care for is struggling with depression that hasn’t improved with standard treatment, there are options. Book an appointment or make an enquiry to explore whether ketamine therapy or other advanced treatments may be right for you.
