Rapid, evidence based relief for treatment-resistant depression. Esketamine nasal spray (Spravato®) offers a new pathway forward when standard antidepressants have not worked.
A new approach to treatment-resistant depression
Esketamine is a derivative of ketamine, delivered as an intranasal spray (Spravato®) and approved for the treatment of treatment-resistant depression. It is administered under strict medical supervision in accredited healthcare settings.
Unlike traditional antidepressants, which act on serotonin and noradrenaline pathways, esketamine works on the glutamate system, targeting NMDA receptors in the brain — influencing mood pathways in a fundamentally different way.
If you have tried multiple antidepressants without adequate relief, esketamine treatment may offer a new option.
Esketamine is not a first-line treatment. It is typically considered for patients who have treatment-resistant depression (failure of two or more antidepressants) and experience persistent depressive symptoms despite ongoing care.
Esketamine treatment offers rapid relief for treatment-resistant depression by targeting brain pathways differently from standard antidepressants — providing a new option for patients who have not responded to multiple medication trials.
A different pathway forward.
Esketamine works on the brain’s glutamate system rather than the serotonin or noradrenaline pathways targeted by traditional antidepressants. By acting on NMDA receptors, it promotes rapid neuroplasticity — helping to "reset" dysfunctional neural circuits involved in mood, stress, and emotional processing.
This mechanism is one reason many patients experience improvement within hours to days, rather than weeks.
Esketamine treatment is a guided, medically supervised experience. From assessment through dosing to recovery, we guide you through each step in a safe, supportive environment.
Treatments are conducted in a calm, supervised clinical setting with regular follow-up care. With a personalised approach, we ensure safety, maximise benefits, and track your progress over time.
Following referral, we begin with a comprehensive medical and psychiatric assessment, including screening tests, questionnaires, and a medical consultation. This ensures esketamine treatment is safe, appropriate, and tailored to your needs before creating a personalised treatment plan.
The nasal spray is self-administered under clinician guidance in a calm, supervised clinical environment. Blood pressure and mental state are monitored throughout the session, with your comfort and safety as our priorities.
You will remain under observation for approximately two hours after dosing, while our team monitors your vitals and ensures any short-term effects have settled. You will need to arrange transport home and avoid driving for the rest of the day.
Treatment usually follows an induction phase (twice weekly for 4 weeks), followed by maintenance sessions spaced over time depending on response. We provide regular follow-up reviews to track your progress, monitor effectiveness, and ensure ongoing safety — coordinating with your broader care team for comprehensive support.
Our treatment team brings extensive experience in esketamine treatment, ensuring safe, effective, and personalised care at every stage.
We work closely with your existing healthcare providers to deliver coordinated, evidence-based care. Every treatment plan is tailored to your unique needs, with your safety, comfort, and recovery as our highest priorities.
Led by specialists in psychiatry, our clinicians bring expertise in esketamine and other advanced mental health treatments — ensuring safety, effectiveness, and personalised care throughout your treatment.
Designed for patients and healthcare professionals, our resource materials provide clear, evidence-based information on esketamine treatment — covering benefits, risks, preparation, and care pathways.
Explore Anodyne’s library of downloadable factsheets and resources. From information booklets to clinical factsheets, our resources make complex information easy to understand. Download, share, and use them to support informed decisions.
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Take the first step toward relief with Anodyne’s advanced, evidence-based treatments for treatment-resistant depression.
If you or your patient is struggling with treatment-resistant depression, our team can help determine whether esketamine treatment or alternative therapies may be appropriate. Book an appointment or make an enquiry to explore your options today.
